Tapasin

Identification of RNA-binding protein hnRNP C targeting the 3′UTR of the TAP-associated glycoprotein tapasin in melanoma

Melanoma cells exploit hnRNP C to bind a repressive site in tapasin (TAPBP) 3′UTR, lowering HLA‑I antigen presentation. Genetic/biochemical disruption of this interaction restores tapasin and boosts HLA‑I surface levels—implicating hnRNP C as a biomarker and target for T‑cell–based immunotherapy.

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Identification of RNA-binding protein hnRNP C targeting the 3′UTR of the TAP-associated glycoprotein tapasin in melanoma
Unconventional microRNA role: Enhancing the human leukocyte antigen class I antigen processing pathway via interacting with a silencer
miR-155-5p disrupts a silencer motif in tapasin (TPN/TAPBP) 3′UTR to elevate HLA-I antigen processing and cell-surface expression.
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Unconventional microRNA role: Enhancing the human leukocyte antigen class I antigen processing pathway via interacting with a silencer